Jared Padalecki (Sam Winchester): They bring us in to the WB lot, and I’m sitting there, and in walks this really pretty dude who I had never seen before. We met and we’re waiting around, and usually in a test situation there are three or four people at least for each character and they’ll do a chemistry read.
Jensen Ackles (Dean Winchester): It was just immediate chemistry. There was an ease to it. There was a familiarity to it. Once we got into it with each other, it just fell in place and it came… not easy, but definitely a little easier than my experiences in the past. I think the importance of that bond and that relationship was verbalized by Kripke when he sat us down and said, “this begins and ends with you,” and not only how we relate to each other on screen, but also off screen. There was an importance stamped into [that bond] very early on. (X)