‘Supernatural’ at 200: The Road So Far, An Oral History (Variety, 2014)

Jared Padalecki (Sam Winchester): They bring us in to the WB lot, and I’m sitting there, and in walks this really pretty dude who I had never seen before. We met and we’re waiting around, and usually in a test situation there are three or four people at least for each character and they’ll do a chemistry read. 

Jensen Ackles (Dean Winchester): It was just immediate chemistry. There was an ease to it. There was a familiarity to it. Once we got into it with each other, it just fell in place and it came… not easy, but definitely a little easier than my experiences in the past. I think the importance of that bond and that relationship was verbalized by Kripke when he sat us down and said, “this begins and ends with you,” and not only how we relate to each other on screen, but also off screen. There was an importance stamped into [that bond] very early on. (X)

Jared Padalecki on the episode that made him “miserable” (from ew.com)

The show has handled death any number of ways, whether it’s Dean’s emotional plea to bring Sam back to life in season 2, or on the other end of the spectrum, Dean dying over and over for comedic purposes in season 3’s “Mystery Spot,” when the brothers find themselves in a world created by the Trickster.

And yet, the show’s more comedic handling of death resulted in an hour that star Jared Padalecki will never forget. “I feel like all I can do is be totally honest as Sam Winchester, and he’s not a funny guy,” Padalecki says. “The way I treat the death, like ‘Mystery Spot,’ which was a kind of comedic episode, was miserable for me. I was crying day in and day out. I mean it. This is not hyperbole. That was a miserable, miserable, miserable week in my life.”

“I could only treat it like it was reality,” Padalecki says, even surprising co-star Jensen Ackles with his revelation. “I had to treat it like Sam, and Sam would be mortified. When [Dean] kept on getting shot, I was playing, as best as I could, my brother is dead. My brother is dead in my arms. He got shot. A f–king piano fell on him, whatever it was. For me, it was miserable because I was legitimately trying to convince myself that my brother had died from some funny way, but it’s not funny if it’s happened to you.”

(X)